Pharmacosomes-An Immense Potential Vesicular Constructs

Various Colloidal vesicular system employed in controlled and targeted delivery system are liposomes, Niosomes, Virosomes, Immuuoliposomes, Transferosomes and Pharmacosomes. Pharmacosomes are the colloidal dispersions of drugs covalently bound to lipids and may exist as ultrafine vesicular, micellar or hexagonal aggregates, depending on the chemical structure. Because the system is formed by linking a drug (pharmakon) to a carrier (soma) they are called pharmacosomes. They are amphiphilic lipid vesicular systems that have shown their potential in improving the bioavailability of poorly water soluble as well as poorly lipophilic drugs. They are bearing unique advantages over liposomes and niosomes vesicles that can pass through biomembranes efficiently. They potentially delivery the drugs directly to the site of infection, leading to reduction of drug toxicity with no adverse effect.