Nanosuspensions: A Promising Nanocarrier Drug Delivery System

For most of the active pharmaceutical ingredients, poor aqueous solubility and hence low bioavailability and erratic absorption is the common difficulty observed by the formulation development scientist. Nanotechnology drug delivery has gained much interest as a way to improve the solubility problems. Nanosuspension is biphasic system which consists of pure drug particles are dispersed in an aqueous vehicle of particle size less than 1000 nm, and system is stabilized by surfactant. Nanosuspension provide us with useful tool for formulating an poorly water soluble drug may be due to the properties of nanosuspension, their low production cost, ease of manufacture and scale-up. This system helps in dissolution and thus improves bioavailability of poorly water soluble drugs and holds the promise in their aspects of drug delivery. The present article reviews the various methods, manufacturing challenges and their applications as nanocarrier drug delivery system.