Effect of Combination of Hydrophilic and Hydrophobic Polymers on Transdermal Drug Delivery Systems Properties

The matrix-type controlled transdermal drug delivery systems were prepared by solvent evaporation method using methanol: dichloromethane (1:1) as solvent for HPMC and ethanol as solvent for Eudragit RL 100 and Eudragit RS 100 (ERL 100 and ERS 100). In the evaluation tests it was found that formulation batch L1 (96.40%) was having more release as compared to formulation L2 (95.52%) but later had much better physicochemical properties and shown cumulative percentage diffusion 96.60% in 24 h. The transdermal patches were evaluated for their In vitro dissolution test and in vitro diffusion test, skin irritation test. Scanning electron microscopy was performed to characterize the transdermal patch.