Development and Evaluation of Propranolol Hydrochloride Floating Matrix Tablets Using Combination of Natural and Synthetic Polymers

In the present investigation, an attempt was made to formulate Propranolol hydrochloride sustained release floating matrix tablets using dried Hibiscus rosa-sinensis leaves mucilage and to study its release retardant activity in combination with hydroxypropyl methyl cellulose grades. Different floating matrix tablets of Propranolol HCl were formulated. The floating matrix tablets found to have better uniformity of weight, hardness, friability and drug content. The swelling behavior, release rate characteristics and the invitro dissolution study proved that the dried Hibiscus rosa-sinensis leaves mucilage can be used as a matrix forming material for preparing sustained release floating matrix tablets. The release rate followed zero-order release kinetics and the data was fitted in the Peppas plots. The exponential coefficient from the Peppas plots was found to be in between 0.55 to 0.64, indicating non-fickian mechanism of drug release.