Liposome as a Drug Delivery System-A Review

A liposome is a spherical vesicle with a membrane composed of a phospholipids bilayer used to deliver drug or genetic material into a cell. Liposomes can be composed of naturally-derived phospholipids with mixed lipid chain like egg phosphatidylethonalimine or of pure components like DOPE (dioleolylphosphatidylethanolamine). There are number of the structural and nonstructural components of liposomes, major structural components of liposomes are: phospholipids and cholesterol. Liposomes are usually classified according to their lamellarity and size is MLV, LUV, SUV. Various methods used for the preparation of liposome are Passive loading techniques, Active loading technique. Therapeutic Application of Liposome are Liposome as drug/protein delivery vehicles, Liposome in antimicrobial, antifungal and antiviral therapy, Liposome in tumour therapy. Liposome in gene delivery, Liposome in immunology, etc.