1Gyan Vihar School of Pharmacy, SGVU, Jaipur, India
2Lordshiva College of Pharmacy, Sirsa, Haryana, India
*Corresponding Author: Mr. Vijay Singh Jatav, Gyan Vihar School of Pharmacy, SGVU, Mahal Road, Jagatpura, Jaipur, India Phone no. +919887718159 Email: jatavvijay@rediffmail.com
Online published on 21 February, 2013.
The present study is to formulate the matrix type transdermal patches of Nebivolol hydrochloride as a model drug with combination of HPMC K100M and ERS-100 to minimize the dose of the drug for lesser side effect.
Matrix type transdermal patches containing Nebivolol hydrochloride were prepared using two polymers by solvent evaporation technique. Aluminium foil cup method was used as a substrate. Polyethylene glycol (PEG) 400 was used as plasticizer and Dimethyl sulfoxide was used as penetration enhancer.
The physicochemical parameters like weight variation, thickness, folding endurance, drug content, Percentage moisture absorption and Percentage moisture loss were evaluated. All prepared formulations indicated good physical stability and no skin irritation. In-vitro drug release and drug permeation studies of formulations were performed by using Franz diffusion cells. Formulation prepared with hydrophilic polymer containing permeation enhancer showed best in-vitro skin permeation through rat skin (Wistar albino rat) as compared to all other formulations.
On the basis of in vitro drug release through skin permeation performance, Formulation F1 was found to be better than other formulations and it was selected as the optimized formulation.
Nebivolol Hydrochloride, Transdermal patch, polymers, Solvent evaporation technique, Skin permeation
