Research Journal of Pharmaceutical Dosage Forms and Technology
  • Year: 2012
  • Volume: 4
  • Issue: 6

Efficient and viable synthesis development for Tiaprofenic Acid in pharmaceutical industries

  • Author:
  • K. Raghubabu1,, N. Mohan1, B. Kalyanaramu2,, C. Ramadas3, M. Narayanarao3
  • Total Page Count: 2
  • Page Number: 318 to 319

1Department of Engineering Chemistry, AU College of Engineering (A), Andhra University, Visakhapatnam-530003, AP (India)

2Department of Chemistry, Maharajah ’s College (Aided & Autonomous), Vizianagaram-535002, AP (India).

3Tyche Industries Limited, 11-15-28, Siris Complex, Doctors Colony, L B Nagar, Hyderabad-500074, India

*Corresponding Author: Raghubabu K., Department of Engineering Chemistry, AU College of Engineering (A), Andhra University, Visakhapatnam-530003, AP (India) E-mail: drraghualways@yahoo.co.in

** Email: Kalyanaramu23566@gmail.com

Online published on 21 February, 2013.

Abstract

An industrially efficient method was developed to synthesize of tiaprofenic acid (5-benzoyl-alpha-methyl-2-thiopheneacetic acid) (1) which is a very important pharmaceutical compound having anti-inflammatory and analgesic activity. Sodium salt of propionitrile is reacted with 5-benzoyl-2bromothiophene (4) to yield nitrile crude (5) and further hydrolysis to give tiaprofenic acid (5-benzoyl-alpha-methyl-2-thiopheneacetic acid) (1).

Keywords

Sodamide, Propionitrile, Anti-inflammatory, Tiaprofenic acid, NSAID