Formulation and Comparative Evaluation of Aceclofenac Oral Disintegrating Tablets Using Natural Disintegrants

In recent years, plant derived polymers have evoked tremendous interest due to their diverse pharmaceutical applications such as diluents, binder, disintegrant in tablets, thickeners in oral liquids, protective colloids in suspensions, gelling agents in gels and bases in suppository. The main objective of present study was to formulate Aceclofenac oral disintegrating tablets using different natural gums and mucilage's and to study their functionality as disintegrating agents for oral disintegrating tablets. Physicochemical properties and acute toxicity studies of dried powders of isolated mucilage's were studied. Dispersible tablets of Aceclofenac were prepared by direct compression method using different natural disintegrants and Sodium Starch Glycolate. The evaluation parameters revealed that the formulated tablets had good appearance and better drug release properties. The study revealed that natural disintegrants were effective as super disintegrant.