Formulation and Evaluation of Extended Release Tablets of Alfuzosin HCl

Developing oral extended release tablets for highly water soluble drugs with constant release rate has always been a challenge to the pharmaceutical technologist. The present work is focused on controlling the release of highly water soluble Alfuzosin HCl from hydrophylic matrices prepared using hypermellose.

Alfuzosin HCl tablets were prepared by direct compression method using hypermellose polymer to control release of highly water soluble drug alfuzosin HCl which is having short half life primarily used as antihypertensive drug. The formulations developed from F1 to F8. With in these formulations F8 was found to have optimised drug release of 86% for 20 hours, the kinetic release studies were conducted for the optimised formulation and the best fit model was found to be Higuchi (diffusion) model.