Dendrimers: Therapeutic Activity and Application

Dendrimers represent a novel class of structurally controlled macromolecules derived from a braches upon branches structural motif. These consist of highly branched moieties that radiate from a central core and synthesizes through a stepwise repetitive reaction sequence. The structural advantage of dendrimers such as size, shape, surface and interior chemistry flexibility and topology by virtue are leads to play an important role in the field of nanotechnology, pharmaceutical and medicinal chemistry. Dendrimers have emerged as highly promising drug delivery molecule because of their unique structure and properties. Solubility enhancement is an important aspect of dendrimers and this is a synergy with site specific drug delivery. The hydrophobic guests when entrapped in the hydrophobic channels of dendrimers are solubilised in aqueous solution. Extracellular matrix of tissue particularly vascular tissue it contains a high concentration of negatively charged glycosaminoglycans which are involved in regulation of cell motility cell proliferation in the regulation of enzyme activity. Extra cellular matrix can be used as a substrate for binding and retention of drug delivered intra vascularly. Recently dendrimers have caused an explosion in biomedical science and created interest in the discovery of the drugs by virtue of their therapeutic value. The dendrimer polymer suggest that they are promising drugs wound healing, bone mineralization cartilage formation, tissue repairing topical treatment for AIDS to prevent HIV transmission. It also acts as an anti prion, anti Alzheimer, anti coagulants, anti dots, anti inflammatory and anti cancer agents.