Taste Masking, Formulation and Evaluation of Orally Disintegrating Tablet of Anti-histaminic Drug

In case of orally disintegrating tablet, problem of bitter taste of the drug is often encountered. The taste masking of Anti Histaminic drug by using Polacrilin potassium has been done and evaluated for different degree of cross linking for better taste masking and also evaluated disintegration tablet characteristics by using different super disintegrant at different concentrations. Formulation containing 1:3 ratio of Drug to Polacrilin potassium completely masked the bitterness of drug without discoloration of complex. Cross povidone with approx. 12%, 8.23% intra and rest extra granular found to be optimized for lowest disintegration time as well as best in vitro drug release and also stable for 3 months at accelerated stability study. The patient-friendly dosage form of intensely bitter API which is useful one especially for pediatric, geriatric, bedridden, non cooperative and gastroparesis patients can be successfully formulated using this technology.