1Department of Pharmaceutics, K.L.E.S's College of Pharmacy, Ankola-581314, Karnataka, India
2Department of Pharmacognosy, K.L.E.S's College of Pharmacy, Ankola-581314, Karnataka, India
3Department of Pharmacology, K.L.E.S's College of Pharmacy, Ankola-581314, Karnataka, India
*Corresponding Author: Sachin R Patil, Department of Pharmaceutics, K.L.E.S's College of Pharmacy, Ankola-581314, Karnataka, India Phone: 08388-329400 Fax: 08388-230252 E mail: srpatil78@gmail.com
Online published on 22 March, 2013.
The present study is designed to investigate anti-inflammatory activities of ethanolic extract of male flowers (inflorescences) of Borassus flabellifer L. (Arecaceae).
Acute inflammation models like histamine-induced and eggalbumin-induced rat paw edema model and xylene induced ear oedema in mice were employed to investigate the anti-inflammatory activity. The biochemical parameters like serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), lipid per oxidation and alkaline phosphatase (ALP) were also estimated as supportive study.
The extract at doses 150mg/kg b.w. and 300mg/kg b.w. and diclofenac sodium (standard) showed significant anti-inflammatory in all the models, as compared to control (p< 0.0001). The extract and standard drug also showed significant (p<0.0001) results for biochemical parameters.
The results of the present further confirm the use of Borassus flabellifer L. traditionally for the treatment of painful inflammatory conditions.
Borassus flabellifer L, inflorescences, male flowers, antiinflammatory, histamine, egg-albumin, SGOT, SGPT, Lipid per oxidation, ALP
