Research Journal of Pharmacognosy and Phytochemistry

The antiulcer activity of 50% hydroethanolic leaf extract of Ruellia tuberose L. and Dipteracanthus patulus (Jaca) was evaluated in rats against pylorus ligated gastric ulcer model. The plant extract were administered orally at a dose of 500mg/kg and famotidine at the dose of 20 mg/kg (standard drug). Ulcer index was common parameter studied in the ulcer model, further the gastric pH, total and free acidity, gastric volume and antioxidant leaves such as SOD, CAT, GSH and the effect on LPO and protein were analysed. Both the extracts produced significant reduction in ulcer index, along with increase in the antioxidant enzyme and protein leaves as compared to control group and the lipid peroxidation was reduced in the treated and drug administered groups. Thus the plant extracts possess, significant antiulcer as well as antioxidant property.