Formulation and evaluation of fast dissolving film of labetalol hydrochloride

The present study was aimed to formulate and evaluate oral fast dissolving oral films of Labetalol Hydrochloride using different grades of water soluble polymers HPMC (E5, E15, E50). The suitable plasticizer Propylene Glycol were selected for the preparation of the film. The films are prepared by solvent casting method. Nine formulations (F1-F9) of Labetalol Hydrochloride films were prepared and films were evaluated for appearance, weight variations, thickness, folding endurance, surface pH, drug content and In-vitro dissolution studies gave satisfactory result. F2 was found to be the best and acceptable formulation which contains HPMC E5 whose drug content was about 99.06±0.025% and percentage (%) drug release in 9 min. is about (99.2±0.152%) high as compared to other formulation and has surface pH of (6.6±0.126) obtained in simulated saliva (pH buffer 6.7).