In silico studies for Skin Whitening effect of African Tulip Flowers

This research was conducted in-silico and explores the bioactive compounds of the African Tulip tree (Spathodea campanulata) for bioactivity against the human Tyrosine Kinase using AutoDock Vina. Given that Tyrosine Kinase plays a role in the cell signaling processes such as the proliferation or the differentiation of a cell, it is still a significant candidate for drug discovery especially for antioxidant and anti-inflammatory activity. In the present work, antioxidant activity is explored in the flower extracts of S. campanulata to determine if bioactive components present in these extracts are contributing to free radical scavenging activity. Docking experiments were conducted on principal phytochemicals, Ajugol, Catechin, Niranjinin, Phytol, KOJIC ACID, Alpha and Caffeic Acid, to unravel their binding affinities towards the biomolecule. The information about constituents and their activity was collected from Indian Medicinal Plants, Phytochemistry and Therapeutics (IMPPAT). These results establish the presence of considerable binding affinities with the enzyme that were primarily stabilized by hydrogen bonding, hydrophobic interactions, and pi-alkyl interactions. The maximum interactions were found to be present in the cases of Catechin and Caffeic Acid and thus place them in the role of being potential Tyrosine Kinase Inhibitors. This study targets the bioactive potential of Spathodea campanulata and the potential modulation of Tyrosine Kinase bioactivity.