Department of Pharmaceutical chemistry, JKKMMRF College of Pharmacy, Ethirmedu, Komarapalayam 638183, Namakkal Dt, Tamilnadu, India
*Corresponding Author: R. Vijay Amirtharaj, JKK Muniraja Medical Research Foundation College of Pharmacy, B-Komarapalayam-638 183. E-mail: mukeshrohith@yahoo.com Ph: +91 9865610568
Online published on 21 March, 2013.
The methanol extract of aerial part of Clerodendrum inerme were investigated for anti-inflammatory and analgesic at the dose 200 mg/kg, body weight. The experimental paradigms used were carrageenan, induced pedal edema for anti-inflammatory activity, acetic acid induced writhing methods were used to assess analgesic activity. In acute phase inflammation, a maximum inhibition 60.17% (P< 0.01) was noted at the dose of 200 mg/kg after 3 h of treatment with methanol extract of Clerodendrum inerme (MECI) in carrageenan, induced pedal edema respectively. The extract also produced significant (P< 0.01) analgesic activity in both paradigms. This study exhibits that the methanol extracts of aerial part of Clerodendrum inerme possess anti-inflammatory and analgesic activities.
Clerodendrum inerme, Anti-inflammatory, Analgesic
