Pharmacognostical and Pharmacological Evaluation of the Polyherbal Extract on Rodents

Hyperlipedemic is the greatest risk factor for coronary heart diseases. It is characterized by elevated serum total cholesterol, low density lipoprotein, very low density lipoprotein and decreased high density lipoprotein levels. Methanolic extract of Terminalia arjuna (bark), Phyllanthus emblica (fruits), Withania somnifera (leaves), Convolvulus pluricaulis (whole plant), Piper betle (leaves), Allium sativum (bulb), Piper longum (dry fruits), Zingiber officinale (rhizomes), Tribulus terrestris (whole plant) and Cardamom (dry fruits) these herbs were tested against high cholesterol diet induced hyperlipedemic in adult albino rats. The therapeutic dose is calculated as 200mg/kg as per the toxicity guidelines OECD 423. Fenofibrate 65mg/kg is used as a standard drug. The methanolic extracts shows a significant decrease in the levels of serum cholesterol, Triglycerides, LDL, VLDL and significant increase in the level of serum HDL against high cholesterol diet induced hyperlipedemic rats. The results shows that the polyherbal extract possess significant (p<0.001) antihyperlipedemic activity suggesting the potential role in coronary artery disease and in hyperlipidemia.