Comprative study of Clinical Parameters of Pneumocystis pneumonia with healthy controls in Vindhya Region

Pneumocystis is a genus of unicellular fungi found in the respiratory tracts of many mammals and humans. Distinct genomic variability exists between host-specific members of the genus. The patient population comprised 83 females (81.7%) and 19 males (18.3%). The mean age of the patients when they received their first biologic agent was 58.0 years (range, 14 to 86 years). The mean observation period was 16.6 months (range, 2 weeks to 60 months) and 21 patients (20.1%) received TMP/SMX prophylaxis. A total of 38 patients (37.7%) had coexisting pulmonary disease, 44 patients (43.2%) received glucocorticoid therapy and the mean dose (±SD) of glucocorticoid (converted to the prednisolone (PSL) equivalent) was 4.46 mg ± 3.64 mg. A total of 78.5% of patients were given MTX, and the average dose of MTX in patients treated with MTX was 8.96 mg/wk. Nine (1.28%) of the one hundred two patients developed PCP, and none of the patients in the group treated with TMP/SMX prophylaxis developed PCP. There are 81patients, the mean age in their group was significantly older (68.9 years vs. 55.3 years); the serum level of IgG was significantly lower (1, 496 mg/dl vs. 1, 619 mg/dl); the dose of MTX was significantly lower (6.09 mg vs.7.28 mg); and the ratios of patients treated with glucocorticoids, PCP complicated with coexisting pulmonary disease and PCP complicated with DM were significantly higher (53.9% vs. 40.8%, 72.3% vs. 29.1% and 21.3% vs.10.5%, respectively).