1Department of Pharmacy, Girijananda Chowdhury Institute of Pharmaceutical Science, Hathkhowapara, Azara, Guwahati – 781017, Assam, India
2Department of Pharmacy, Gupta College of Technological Sciences, Asansol-713301, West Bengal, India
*Corresponding Author: Indranil Chanda, Lecturer, Department of Pharmacy, Girijananda Chowdhury Institute of Pharmaceutical Science, Hathkhowapara, Azara, Guwahati – 781017, Assam, India. E-mail: i.chanda@rediffmail.com Telephone (O): 0361-2843405 Mob. No. +919957179226
Online published on 20 March, 2013.
The anti-inflammatory activity of the new protease fraction Artocarpain-H extracted from the fruit stem latex of the plant Artocarpus heterophyllus Lam. was evaluated using Carrageenan induced rat paw oedema and Cotton pellet-induced granuloma model. The Artocarpain-H dose dependently inhibited carrageenan induced rat paw edema. It also showed reduction on the granuloma weight in the cotton pellet granuloma method. In the present investigation, as the test drug is effective in both models of inflammation, there is a possibility that these drugs may be effective in acute and chronic inflammation.
Protease, Artocarpain-H, rat paw oedema, granulom
