Research Journal of Pharmacology and Pharmacodynamics

This study was carried out to evaluate the effect of high dose of omeprazole (100mg/kg) on biochemical parameters of liver in albino rats. Albino wistar rats were given into three groups, consisting of 6 animals per group and treated with normal saline (5mg/kg), omeprazole (100mg/kg) and silymarin (25mg/kg) respectively for 14 days. The rats were sacrificed on 14^th day and the serum were collected and estimated for liver parameters. Results showed that rats administrated with omeprazole (100mg/kg) exhibited a significant increase (p< 0.0001). In the levels of SGOT, SGPT, ALP, TB, TP, SC compared with controlled rats and total protein was decreased (p<0.05). histology result of rats in remarkable centrilobular necrosis, confirmed hepatic damage. In conclusion data obtained from this present research indicates that omeprazole at high dose (100mg/kg) may be capable of inducing hepatic cellular damage as evident from histopathological findings. Although further study is required to establish a possible pharmacological mechanism in some other animal species