Study of CNS Depressant activity of Ethanolic extract of Madhuca longifolia Flower

Depression is a heterogeneous mood disorder characterized with regular negative moods, decreased physical activity, feelings of helplessness, and is caused by decreased brain levels of monoamines such as noradrenaline, dopamine, and serotonin. Therefore, drugs restoring the reduced levels of these monoamines in the brain either by inhibiting monoamine oxidase or by inhibiting reuptake of these neurotransmitters might be fruitful in the treatment of depression that has been classified and treated in a verity of ways. Ethanolic extract of Flowers of Madhuca longifolia was used as test drug in the doses 100, 200, 400 mg/kg on Mice of body weight 20-25gm for evaluation of CNS depressant activity on Actophotometer. As dose increased locomotor activity was decreased. The significantly decreased in locomotor activity investigated with 400mg/kg Ethanolic extract of Madhuca longifolia with % inhibition of 55.92% as compared with control group who received distilled water 1.64%. The Ethanolic extract of Madhuca longifolia has shown specifically very negligible decline in locomotor activity with all dose 100, 200%400 mg/kg by 1.46, 12.85 and 55.92 respectively. All extract have showed reduction in the locomotor activity which may be due to the CNS depressant property of the drug.