1Department of Pharmacology, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore – 641402
2Department of Pharmacy Practice, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore – 641402
3Department of Pharmacognosy, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore – 641402
*Corresponding Author E-mail: benitopharma@gmail.com
Online published on 15 June, 2022.
An inflammatory response appears after activation of immune response. Inflammation is a response to remove the primary cause of cell injury. Dead cells, damage tissue sand initiate the repair process. Inflammation may be of two types acute and chronic. Medicinal plants has a potential source of therapeutic aid has a attended a significant role in all over the world for both human and animals not only in the disease condition but also a potential for maintaining a proper health. The plant Bryophyllum pinnatum species (roots) are evaluated for anti-inflammatory activity.
Anti-inflammatory activity of Bryophyllum pinnatum was evaluated using Carrageenan induced paw oedema, Histamine induced paw oedema and Egg white induced paw oedema.
To prepare methanolic extracts of Bryophyllum pinnatum roots and investigate the anti-inflammatory activity by Carrageenan induced paw oedema, Histamine induced paw oedema and Egg white induced paw oedema.
The result obtained indicates that the extract found to have significant (p<0.0001) anti-inflammatory activity in rats. The extract at the test doses 200mg/kg reduced the oedema induced by carrageenan by 41.26% at 3 h, whereas the standard drug showed 47.35% of inhibition ass compared to the control group.
The methanolic extract of Bryophyllum pinnatum are safe upto 500mg/kg for continues administration and it can be used as anti inflammatory agent without any harmful effects
Inflammation, Oedema, Therapeutic aid, Anti-inflammatory activity, Histamine
