Research on Synthesis and Pharmacological Evaluation of Subsituated Chalcone deriatives for Antimicrobial and Antifungal activity

The Pyrazole nucleus in general and its chemistry has found much more attention during the last few decades because of out-standing biological activities. It acts as Antipyretic, analgesic, anti-inflammatory, kinase inhibitors, and as insecticides. It has good properties as antibacterial, antifungal, and an antiparasitics, as well, considering all those benefits and in continues of our work to synthesize new hetero starting from 1,3-diphenyl-4-carboxaaldehyde, we introduce here in several new pharmacophores, such as pyrimidine, pyramidinethoine and thiazole moieties onto the pyarazole nucleus to obtain compounds with enhanced potency.