Research Journal of Pharmacology and Pharmacodynamics

Galinosa parviflora commonly known as Potato weed widely used in traditional system of medicine for the treatment of diabetes mellitus In the present study, Methanol extract of Galinosa parviflora (MEGP) leaves were subjected to phytochemical investigation and evaluated for antidiabetic activity in STZ induced diabetic rats. MEGP (100, 200 mg/kg) and Glibenclamide (5mg/kg) were administered orally in STZ (60mg/kg, i.p.) induced diabetic rats. In acute oral toxicity (OECD Guide line 423) study, administration of MEGP no mortality upto 1000 mg/kg was observed. OGTT, Fasting blood glucose level, body weight, plasma insulin, were evaluated in normal and diabetic rats. preliminary phytochemical investigation revealed the presence of alkaloids, flavonoids, glycosides, tannins as the major constituents in the methanol extract of Galinosa parviflora. These results suggest that MEGP (200mg/kg) showed antihyperglycemic activity in STZ induced diabetic rats.