Pharmacological and phytochemical investigation of ulcer protective property Catunaregam spinosa Linn.

Ulcer is erosion on the skin or on the mucous membrane specified by outward inflamed dead tissue. The word ulcer is derived from Latin word “ulcus” (genitive: ulceris) which stands for sore, wound or an ulcer. The erosions are most commonly seen on gastric or duodenal mucosa and are referred to as peptic ulcer. Peptic ulcers are the areas of degeneration and necrosis of gastro-intestinal mucosa which is exposed to acid and pepsin secretion. The primary aim of this research is to systematically investigate the antiulcer activity of the hydroalcoholic fruit extract of Catunaregam spinosa. This involves a comprehensive examination of the potential therapeutic effects that the extract may possess in mitigating ulcer formation. Catunaregam spinosa linn. (Thunb.) belongs to the family Rubiaceae. The genus Catunaregum (XeramphisRafin.) Consist of about10species, out of which two are in India. In Ayurveda it is known as madanaphala.

The study investigated the hydroalcoholic extract of Catunaregam spinosa linn.for its potential anti-ulcerogenic effects and its influence on various gastric parameters in rats with ethanol- induced ulcers. The extraction process yielded 7.63% from hydroalcoholic solvent, significantly higher than the 1.02% yield from pet ether extraction. Phytochemical screening of the hydroalcoholic extract identified the presence of alkaloids, glycosides, flavonoids, proteins, saponins, and diterpenes, while phenols, carbohydrates, and tannins were absent.