Research Journal of Pharmacology and Pharmacodynamics

Bronchitis is a chronic obstructive pulmonary disease. It can be either acute or chronic, depending on its severity. The main Etiology of this disease is cigarette smoking. So for this present bronchitis activity we induced bronchitis in wistar rats by Cigarette smoke model. Smoke has a number of toxic substances leading to impairment of ciliary function, increase the airway resistance, mucosal gland hypertrophy leadings to increase mucosal discharge, produces inflammatory changes by recruiting neutrophils and macrophages. And its activate the transcription of nuclear factor and IL-6. The Hydro alcoholic extract of Grewia hirsuta Vhl whole shrub were screened for anti-bronchitis activity by using cigarette smoke in-vivo animal model on rats. The outcomes of these investigations showed that the 200 mg/kg dose of Grewia hirsuta was more significantly (p<0.001) efficacious as an anti-bronchitis activity. The anti-bronchitis properties of the extract attributed to a decrease in IL-6 levels, total WBC count, C-reactive protein, neutrophil and lymphocytes infiltration. Additionally, the cytology of the lungs and BALF were examined to see whether the negative control group had higher lymphocyte infiltration than the treatment group. The histopathology investigation revealed that the treatment group of the animals had less leucocyte infiltration and bleeding than the negative control group. For the Grewia Hirsuta vhl comparative investigation, a Bronchodilator 2 mg/kg salbutamol was employed.