Antioxidants used in streptozotocin induced diabetic nephropathy: A concise review

Diabetic nephropathy is a major complication of diabetes and a leading cause of end-stage renal failure throughout much of the world. The synthetic drugs are effective in controlling the blood sugar but with many other complications. To overcome this, the need for natural antioxidants, this may be used as a dietary supplement to prevent diabetic nephropathy. Most drugs found to cause nephrotoxicity which exerts toxic effects by one or more common pathogenic mechanisms. Among them, Streptozotocin is the most frequently used drug to induced diabetic nephropathy in rodents offers relevant models to study the effect of antioxidants. The model has so far been used by many researchers to study the effect of drugs in diabetes. In this review, we compiled several antioxidants that are used in the management of Streptozotocin induced diabetic nephropathy with their parameters evaluated.