Exploring Anti-inflammatory effect of Holarrhena antidysenterica and Coriandrum sativum Linn in the Digestive System disease IBD in Rats

Inflammatory bowel disease (IBD) is an idiopathic chronic inflammatory gastrointestinal disease that includes Crohn's disease and ulcerative colitis. Symptoms include diarrehoea, stomach discomfort, blood in the stool and other similar issues. Since there are no safe and effective treatments for gut inflammation, new treatments developed to efficiently treat the disease's symptoms and implications.

The development of collitus was promoted by the injection of 3% acetic acid into the rat colon through the rectum. Macroscopic, biochemical, histological and disease activity scoring of the colon were performed after 5 days of infusion to evaluate colonic damage. A study on the activity of Holarrhena antidysenterica and coriander sativum Linn was investigated in collitus-induced 36 albino rats randomized into five groups (n=6). Control Group I given the normal saline, Group II give the Acetic acid 3% through rectum, Group III give the Budesonide (0.5mg/kg) through oral. Group IV give the aqueous extract of Holarrhena antidysenterica (HA) (40mg/kg) through oral, Group V give the aqueous extract of Coriander sativum Linn. (CS) (40mg/kg) through oral and in Group VI given the combination of both extract HA and CS. Both treatment drugs given 2 days before induction of collitus.

A significant colon inflammatory response to acetic acid infusion is observed macroscopically and histopathologically. Additionally, it results in a decrease in GSH, SOD and an increase in MPO level. Thus in current study aq. extracts of Holarrhena antidysenterica and Coriandrum sativum were administered for 7 days i.e. commencing 2 days prior to the induction of acetic acid and continuing for 5 days after. Compared to disease control there was a significantly reduced amount of macroscopic damage and disease activity score. Additionally, it increased intestinal levels of reduced GSH, SOD and significantly decreased MPO levels.

Inflammation is inhibited by coriander sativum while the primary symptoms of IBD are inhibited by Holarrhena antidysenterica. Inflammatory bowel disease can be treated more effectively with a combination of these two medications which also eliminates the side effects of glucocorticoids (Budesonide).