Exploring the Cardioprotective effects of Alpha Keto-Analogues in Isoproterenol-Induced Myocardial Infarction in Rats

Myocardial infarction (MI) is one of the major sources of morbidity and mortality worldwide. Alpha-Keto-analogues (KA) gets changed in to the essential amino acids in the body via transamination and could improve nutritive deficiencies produced by protein- restricted diets. In this study, cardio protective effects of KA in isoproterenol (ISO) induced myocardial infarction in rats was evaluated. Rats were randomly divided into various groups. Group I^st - Vehicle control; Group II^nd - Toxic control (ISO 85mg/kg, i.p.); Group III^rd and IV^th – KA (20 and 40mg/kg, p.o respectively) with the ISO and Group V^th- Amlodipine (5mg/kg) with ISO for the 14 days. Then after 24hours of the last dose, hemodynamic were assessed and animals were sacrificed and biochemicals as well as histopathological changes were measured. ISO treatment with significantly deviated hemodynamic parameters (Systolic Arterial Blood Pressure (SAP), Heart Rate (HR), Diastolic Arterial Blood Pressure (DAP) and Mean Arterial Blood Pressure (MAP), biochemically limitations Lactate Dehydrogenase (LDH), Creatine Kinase-MB (CK-MB) and Troponin-T) and antioxidant symbols Superoxide dismutase (SOD), Thiobarbituric Acid Reactive Substance (TBARS), Catalase and Glutathione (GSH). Pre-treatment by KA, meaningfully bring back the antioxidant position, hemodynamic profile and cellular construction of the heart. KA showed cardio protection which was reflected by restoration of oxidative stress, cardiac membrane damage, hemodynamic and histopathological change.