Investigating the Cardioprotective effect of Acacia arabica extract in Isoproterenol-induced Myocardial Infarction in Rats

Despite many advances in medical intervention, cardiovascular diseases (CVD) are the leading cause of death worldwide. Among them, the ischemic heart diseases, especially the acute myocardial infarction (MI), are present in all of the most horrific values. The present investigation aimed to evaluate the cardioprotective effect of Acacia arabica extract against Isoproterenol-induced myocardial infarction in rats. A. arabica (100mg/kg and 200mg/kg, p.o) was given to rats for 15 days. On the 14th and 15th days, MI was induced by a single dose of Isoproterenol (200mg/ kg, s.c.). Serum and heart tissues were collected at the conclusion of the experiment (i.e., on day 16), and total cholesterol (T), high density lipoprotein (HDL), triglyceride, and malondialdehyde, superoxide dismutase, catalase (T), reduced glutathione (GSH), and body weight were measured. Administration of Isoproterenol in control rats showed a significant (P<0.001) increase in serum cholesterol alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and low-density lipoprotein (LDL). There was a significant increase (P<0.01) in the levels of heart tissues as compared with respective control groups. Rats treated by A. arabica significantly (P<0.01) decreased ALT, AST, ALP, LDL, and TC. Moreover, there was an increased CAT and GSH levels in rat treated with A. arabica, when compared to the control group. In experimentally induced MI in rats, A. arabica (100 and 200mg/kg p.m.) is effective in controlling blood LDL levels and reducing cardiac complications.