Evaluation of the Central and Peripheral Analgesic Activity of Sansevieria roxburghiana Leaf Extract in Albino Mice

The investigation assessed the analgesic potential of Sansevieria roxburghiana leaf extracted by Soxhlet extraction in traditional in vivo models in albino mice. Although it is traditionally known as a therapeutic resource, S. roxburghiana has not been comprehensively investigated scientifically concerning its ethno-medicinal uses. Analgesic activity of the aqueous extract of the leaves was evaluated using two valid methods: the acetic acid-induced writhing and Eddy Hot-Plate models. These models aim to demonstrate the antagonism of peripheral and central nociception, respectively. There were four groups of animals: control (normal saline), along with the standard (Diclofenac sodium, 10mg/kg) and two-dose-depicted group A (low dose of SRAE 100mg/kg) and group B (high dose of SRAE 200mg/kg) of the aqueous extract. The dose-dependent significant inhibitory effect of abdominal writhes was recorded on extract-treated groups in the model of the acetic acid-induced abdominal writhes, and this effect was dose-dependent, hence, a significant analgesic peripheral activity. There was a significant increase in the latency period in the hot plate assay, indicating central analgesic effects. The large-dose group produced comparable effects to the conventional medicine, making the extract effective in a two-way mechanism of action. The results can support the conventional application of the Sansevieria roxburghiana in pain management and the similarity of using it as a source of bioactive compounds to turn into innovative pain medications. It is justified to conduct further studies by isolating the phytochemicals and screening the mechanistic validation to determine the underlying pathways. The study gives upstream scientific evidence on the pharmacologic importance of S. roxburghiana and will encourage its incorporation into evidence-based herbal medicines.