Research Journal of Pharmacology and Pharmacodynamics
  • Year: 2026
  • Volume: 18
  • Issue: 2

Antidepressant Activity of Toxicodendron succedaneum (l) Kuntze Leaves Extract

1Department of Pharmaceutical Chemistry, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Telangana, Osmania University, India.

2,3Department of Pharmacology, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Telangana, India.

4Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Telangana, India.

*Corresponding Author E-mail: basasunitha@gmail.com

**chmrcp@gmail.com

Abstract

Toxicodendron succedaneum (L.) Kuntze (synonym: Rhus succedanea L.) is a tree in the family of Anacardiaceae. T. succedaneum has been using to treat diarrhoea, nose and gum bleedings, vomiting, dysentery, cough, tuberculosis, fever, asthma, liver ailments, and ear infections in traditional medicines. Phytochemicals such as agathis flavone, rhus flavone, robusta flavone, succedanea flavanone, and volkensi flavone were isolated from this plant species. Various parts of T. succedaneum disclosed such as antibacterial, anticancer, anti-diabetic, anti-inflammatory, antioxidant, and antiviral activities. Anticancer, antioxidant, and antiviral compounds have been identified from this plant species. Further bioactivity and phytochemical studies should make it possible to obtain additional scientific evidence. Based on the presence of the various chemical constituent’s antidepressant activity was performed using aqueous and alcoholic leaves extract.

Keywords

Toxicodendron succedaneum, Rhus succedanea, Antidepressant activity, forced swim test, tail suspension test