Review on the Urolithiatic Activity and Nephroprotective effect of Bryophyllum pinnaum

Bryophyllum pinnatum is a therapeutic herb utilized in traditional healing for remediation numerous health issues. Research indicates that it possesses restorative qualities. characteristics such as lowering inflammation, combating microorganisms, hindering tumors, and accelerating healing curing. It may aid in addressing kidney stones band diabetes. The plant holds natural substances. that provide it these advantages. Even though it is successful in conventional medicine, additional studies are required to comprehend its complete capabilities and guarantee it’s secure for contemporary healthcare applications effect. Urolithiasis, commonly known as kidney stone disease, is a major global health concern with high recurrence and limited treatment options. Synthetic drugs and surgical procedures are often associated with side effects and do not prevent relapse, which has increased interest in plant-based therapies. Bryophyllum pinnatum (Crassulaceae), a medicinal plant used in Ayurveda and folk medicine, exhibits notable antiurolithiatic activity. Phytoconstituents such as flavonoids, alkaloids, glycosides, triterpenes, and phenolics are responsible for its protective effects on the renal system. Experimental studies have shown that extracts of B. pinnatum can prevent calcium oxalate crystal formation by inhibiting nucleation, aggregation, and growth, while also enhancing their dissolution. Its diuretic, antioxidant, and anti-inflammatory activities further aid in reducing urinary stone burden and protecting renal tissue from oxidative stress. These pharmacological mechanisms suggest that Bryophyllum pinnatum may serve as a safe, natural, and effective therapeutic candidate for the management and prevention of urolithiasis, although clinical validation is still required.