1Indira College of Pharmacy, Tathwade, Pune-411 033
2Padmashree Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Dept. of Pharmacology, Pimpri, Pune-18 (Maharashtra), India
3BVDU Medical College and Hospital, Sangli
*Corresponding Author: Dr. M. M. Ghaisas, Padmashree Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Dep. of Pharmacology, Pimpri, Pune-18 (Maharashtra), India. E-mail: ghaisasmm@yahoo.com
Online published on 20 March, 2013.
In the present study, the antiulcer activity of hydroalcoholic extract of roots of Colebrookea oppositifolia Sm. (CO) was evaluated in ethanol and swim stress induced peptic ulcer models. In both the models, various parameters like ulcer index, percentage protection, gastric wall mucus, catalase, reduced glutathione (GSH), lipid peroxidation (LPO) and superoxide dismutase (SOD) were estimated. CO significantly reduced the ulcer index and increased the gastric wall mucus in both the models. CO showed significant antioxidant activity as indicated by significant decrease in LPO and increase in catalase, GSH and SOD levels in stomach tissue homogenate. The results suggest that hydroalcoholic extract of roots of Colebrookea oppositifolia possess antiulcer activity due to its mucoprotective action and antioxidant potential.
Antiulcer, Colebrookea oppositifolia, Antioxidant
