Dept of Pharmaceutical chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati-517503, Andhra Pradesh, India
*Corresponding Author: K.K.Rajasekhar, HOD, Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupathi. Email id: komarlakrs@gmail.com
Online published on 20 March, 2013.
This work evaluated the local anaesthetic activity of milky latex obtained from Calotropis gigantea using three different experimental models in frog and Guinea pig. The latex at dilution 1:10 showed the anaesthetic activity compared to the standard drug xylocaine (0.2%). The methods used are nerve block or lumbar plexus anaesthesia and muscle twitch in frog, infiltration anaesthesia in Guinea pig. It was concluded that latex of Calotropis gigantea (1:10 dilution) exhibited significant local anaesthetic activity.
Calotropis gigantea, milky latex, local anaesthetic activity, nerve block method, muscle twitch method, infiltration method
