Oxidative stress (OS) has been repetitively shown to be a hallmark of many diseases linked with metabolic or vascular disorders. It is produced under diabetic condition and is involved in the progression of pancreatic damage in diabetes. Therefore diabetes represents an ideal candidate for studying the consequences of oxidative stress and its treatment. Diabetes constitutes a multiple source of free radicals, starting very early in the disease, oxidative stress is exposed to have a double impact; on both metabolic and vascular functions. This review describes the many different aspects of oxidative stress in diabetes and proposes possible explanations for the apparent lack of efficacy of antioxidant treatments.
Oxidative stress, Antioxidants, Diabetes
