Evaluation of Antiulcer Activity of Piper betel Leaves Extract in Rats

In Indian traditional system of medicine, the leaves of Piper betel are recommended for the management of peptic ulcer. In light of this, the antiulcer activity of hydroalcoholic extract of Piper betel (HEPB) leaves was evaluated in rats employing the HCl-ethanol, acute stress and pylorus ligation models to induce the experimental gastric ulcers. Pretreatment with Piper betel extract provided significant ulcer protective effect in all the experimental models along with significant increase in gastric pH and decrease in gastric fluid volume. Thus, it can be concluded that hydroalcoholic extract of Piper betel leaves possesses antiulcer activity which can be attributed to its putative mechanism of action.