1Department of Pharmacology, AISSMS College of Pharmacy, Kennedy Road, Near RTO, Pune-411001, Maharashtra, India
2Department of Pharmacology, Faculty of Pharmacy, Dharamsinh Desai University, College Road, Nadia-387001, Gujarat, India
3Indira College of Pharmacy, Pune, Maharashtra, India
4Poona College of Pharmacy & Research Centre, Pune, India
*Corresponding Author: Dr. N.S. Vyawahare, Assistant Professor and Head, Dept. of Pharmacology, AISSMS College of Pharmacy, Kennedy Road, Pune-411001. Tel: +91-20-26058204 (Ext-43), Fax: +91-20-26058208, Email: neerajsv@rediffmail.com
Online published on 20 March, 2013.
In Indian traditional system of medicine, the leaves of Piper betel are recommended for the management of peptic ulcer. In light of this, the antiulcer activity of hydroalcoholic extract of Piper betel (HEPB) leaves was evaluated in rats employing the HCl-ethanol, acute stress and pylorus ligation models to induce the experimental gastric ulcers. Pretreatment with Piper betel extract provided significant ulcer protective effect in all the experimental models along with significant increase in gastric pH and decrease in gastric fluid volume. Thus, it can be concluded that hydroalcoholic extract of Piper betel leaves possesses antiulcer activity which can be attributed to its putative mechanism of action.
Acute stress, antiulcer activity, HCl-ethanol, Piper betel, pylorus ligation
