Department of Pharmacology, JSS College of Pharmacy, Ooty-643001, Tamilnadu, India
*Corresponding Author: Shanish Antony A., Lecturer, Department of Pharmacology, J.S.S. College of Pharmacy, Rocklands, Ooty-643001 Phone: 09345621803 E-mail: shanishantony@yahoo.com
Online published on 20 March, 2013.
We investigated the effect of aqueous and ethanolic extract of Cochlearia armoracia at a dose of 200 and 400mg/kg in 5/6 nephrectomized rats for its nephroprotective activity. Blood samples were collected for the measurement of serum creatinine, urea, blood urea nitrogen, uric acid. Urine samples were collected for the measurement of urine volume, sodium and potassium excretion levels. In nepherctomized rat the blood parameters were significantly increased and urine parameters were significantly altered to disease condition. Both the extracts at a dose level of 400mg/kg showed significant (p<0.01) decrease in serum creatinine, urea, blood urea nitrogen, uric acid and increases urinary volume and sodium and potassium excretions. The present study revealed that the oral administration of aqueous and ethanolic extracts at 400mg/kg dose exhibit a significant nephroprotective activity in 5/6 nephrectomized rat model.
Cochlearia armoracia, Nephrectomized, Nephroprotective
