Department of Chemistry, Mizan-Tepi University, P. O. No 121, Tepi, Ethiopia, East Africa
*Corresponding Author: U.S. Mahadeva Rao Department of Chemistry, Mizan-Tepi University, P. O. No 121, Tepi, Ethiopia, East Africa Tel: + 251 047 55 618 34, 00251 912771092 Fax: + 251 047 335 1473 E-mail: raousm@gmail.com
Online published on 20 March, 2013.
In the present study, anti-ulcerogenic potential of Avocado fruit extract was evaluated using two different models of gastric lesions induced in experimental rats; 1) Indomethacin-induced gastric lesions and 2) Ethanolinduced gastric lesions. Pretreatment with oral administration of the extract of Avocado fruit extract (300mg/kg) prevented the formation of acute gastric lesion induced by both the experimental models: further, treatment with the ethanolic extract of Avocado fruit extract for a period of 15 days significantly reduced the ulcer index, ulcerated surface and significantly elevated the levels of glycoprotein contents in gastric juice.
Avocado, Anti-ulcerogenic effect, Indomethacin-induced gastric lesion, Ethanol-induced gastric lesion, Ulcer index
