1Pad. Dr. D. Y. Patil Institute of Pharmaceutical sciences and research, Pimpari, Pune-411 018, India
2AISSMS College of Pharmacy, Near RTO, Kennedy road, Pune-411 001, India
3Department of Pharmacology, K.L.E.S's College of Pharmacy, Bangalore-560010, India
*Corresponding Author: Dr. Ajay Kshirsagar Pad. Dr. D. Y. Patil I. P. S.R, Pimpari, Pune-411 018, India. E-mail ID: ksagar.ajay@gmail.com Mob: +91-8087306896 Tel: +91-20-27420026 Fax: +91-20-27420261
Online published on 20 March, 2013.
The ethanolic fraction of Calotropis gigantea flowers (CGFE) was evaluated for its possible hepatoprotective potential in Wistar rats. The CGFE (250 mg/kg and 500 mg/kg, bw p.o.) showed a remarkable hepatoprotective activity against cyclosporine-A induced hepatotoxicity as judged from the level of serum markers for liver damage. Cyclosporine-A induced a significant rise in serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and lipid profile levels. The cotreatment of animals with CGFE (250 mg/kg and 500 mg/kg, p.o.) significantly decreased the elevated serum marker enzyme and lipid profile levels near to normal. The activity of the CGFE was comparable to the standard drug, silymarin (100 mg/kg, p.o.). Further histopathological studies support the above finding.
Antioxidant, Calotropis gigantea, Cyclosporine-A, Hepatotoxicity
