Research Journal of Pharmacology and Pharmacodynamics
  • Year: 2011
  • Volume: 3
  • Issue: 1

Hepatoprotective Effect of Pergularia daemia on Cadmium Chloride Induced Toxicity in Rats

  • Author:
  • P. Vinoth Kumar1,, Ch. Sudheer Kumar2, V. Veera Thamarai Selvi1, A. Amala Bricey3
  • Total Page Count: 3
  • Page Number: 19 to 21

1Department of Biotechnology, J.J college of Arts and Science, Pudukottai, India

2Department of Biotechnology, School of Life Sciences, University College of Engineering, JNTU, Kakinada, Andhra Pradesh, India

3Department of Biotechnology, Bharathidasan University, Trichy, India

*Corresponding Author: P. Vinoth Kumar, Department of Biotechnology, J.J college of Arts and science, Pudukottai, India, E-mail: vinothkumarphd@gmail.com, Tel: 09943451023.

Online published on 20 March, 2013.

Abstract

The present study was undertaken to examine the inhibitory effect of the Pergularia daemia on cadmium chloride induced hepatoprotective activity in liver. In rats injected with cadmium chloride, the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), γ -glutamyl transferase (GGT) was significantly (p < 0.05) increased when compared to those values in control rats. The rats administrated with P.daemia extract and cadmium chloride showed a significantly (p < 0.05) decreased levels of serum AST, ALP, LDH and GGT. This study suggested that P.daemia may be implicated as a hepatoprotective agent for therapeutic purposes.

Keywords

Cadmium chloride, Hepatoprotective activity, Pergularia daemia