1Matushree V. B. Manvar College of Pharmacy, Dumiyani, Rajkot, Gujarat-360 440
2Institute of Pharmacy and Technology, Salipur, Cuttack, Orissa-754 202
3Department of Zoology, Berhampur University, Berhampur, Orissa-760 007
4Regional Institute of Pharmaceutical Science and Technology, Abhoynagar, Agartala, West Tripura-799005
*Corresponding Author: S. Acharyya, Matushree V. B. Manvar College of Pharmacy, Dumiyani, Rajkot, Gujarat −360 440. Email: sumanjanmenjoy@yahoo.com Contact Number: +91-9712866020
Online published on 20 March, 2013.
Methanolic bark extract of Acacia suma was evaluated for its antihyperglycemic and antihyperlipidemic activity in alloxan induced diabetes model in rats. The extract was given orally in two different doses (200mg/kg and 400mg/kg) for 28 days and for comparison purpose, Glibenclamide (4mg/kg), an oral hypoglycemic was used as a standard drug. Parameters under study were fasting blood glucose, serum lipids, glycosylated haemoglobin and liver glycogen. The extract showed significant antihyperglycemic activity in dose dependent manner. The orally administered extract significantly reduced elevated lipids and glycosylated haemoglobin in diabetic rats. The extract significantly improved glucose tolerance, body weight and liver glycogen of diabetic rats. It was observed that both glibenclamide and Acacia suma significantly reduced blood glucose as well as produced favorable changes in lipid profile. It was observed that methanolic bark extract of Acacia suma has potential to prevent the secondary complications of diabetes mellitus like atherosclerosis
Acacia suma, Glibenclamide, Antidiabetic, Antihyperlipidemic
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