1Anwarul-Uloom College of Pharmacy, New Mallepally, Hyderabad – 500001, Andhra Pradesh, India
2Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia – Serdang 43400, Selangor Darul Ehsan, Malaysia
3Bharat Institute of Technology, Ibrahimpatnam, RR. Dist., Hyderabad-500001. Andhra Pradesh, India
*Corresponding Author: Syed Safiullah Ghori, Assistant Professor, Department of Pharmacology, Anwarul Uloom College of Pharmacy, New Mallepally, Hyderabad. – 500001, Mob. no.-09848256006
Online published on 20 March, 2013.
The aim of the present study was to investigate the anticonvulsant effect of methanolic and aqueous extracts of the leaves of Anacardium occidentale Linn. on electrically and chemically induced seizures. The methanolic and aqueous extracts of the leaves of A. occidentale (250 and 500 mg/kg.b.w. p.o.) were studied for the anticonvulsant effect on Maximum electroshock (MES) and Pentylene tetrazole (PTZ) induced convulsions in mice. The latency of onset of tonic-clonic convulsions and the number of animals protected from tonic convulsions were noted. AOMEE and AOAQE (500 mg/kg.b.w.p.o) significantly reduced the onset and duration of seizures induced by maximal electroshock (MES). The same dose also protected animals from pentylene tetrazole-induced tonic seizures and significantly delayed the onset of tonic seizures.
Anacardium occidentale, Anticonvulsant Activity, MES and PTZ induced convulsions
