1MAM College of Pharmacy, Narsaraopet, Guntur
2University College of Pharmaceutical Sciences, Kakatiya University, Warangal
3Dept of Biochemistry S.V. University, Tirupati. 517–501
4Sri Padmavathi School of Pharmacy, Tirupati
*Corresponding Author: C. Girish, M. Pharm. Asst. Professor, Division of Pharmacy, Department of Bio Chemistry, S.V. University, Tirupati. – 517–501. E-mail: cgirish.svu@gmail.com, Mobile: +91–92905 34422
Online published on 20 March, 2013.
The anti-ulcer activity aqueous extract of leaves of Cocciniagrandis was investigated in pylorus ligation and ethanol induced ulcer models in experimental rats. In both models the common parameter determined was ulcer index. Aqueous extract of Cocciniagrandis at doses of 250 and 500 mg/kg produced significant inhibition of the gastric lesions induced by pylorus ligation induced ulcer and ethanol induced gastric ulcer.The extract (250 mg/kg & 500 mg/kg) showed significant (P<0.05) reduction in gastric volume, free acidity and ulcer index as compared to control. This present study indicates that aqueous extract of Cocciniagrandis have potential antiulcer activity in the both models. These results may further suggest that the extract was found to possess antiulcerogenic as well as ulcer healing properties, which might be due to its antisecretory activity.
Coccinia grandis, Pylorus ligation, Ethanol induced ulcer model, Ulcer index, Omeprazole
