Antihyperlipidemic and Antiperoxidative Effect of Dibola A Polyherbal Formulation in Alloxan Induced Diabetic Rats

This study was undertaken to investigate the effect of Dibola, a polyherbal formulation composed of medicinal plants on blood glucose, plasma insulin, serum lipid profile and lipidperoxidation in alloxan induced diabetes rats. Dibola, was administered orally (242 mg/kg body weight) for 21 days. The effect of Dibola on blood glucose and plasma insulin in diabetic rats were studied and the levels of lipid peroxides [TBARS and Hydroperoxides] and serum lipids [cholesterol, triglyceride, LDL, HDL and VLDL] were also estimated in alloxan induced diabetic rats. The effects were compared with standard drug Gilbenclamide. Treatment with Dibola and Gilbenclamide resulted in a significant reduction of blood glucose and increase in plasma insulin. Dibola also resulted in a significant decrease in serum cholesterol, increase HDL and reduction in tissue lipid peroxide formation. The effect produced by Dibola was comparable with that of Gilbenclamide. The decreased lipid peroxides, serum cholesterol, increase HDL levels clearly showed the antihyperlipidemic and antiperoxidative effect of Dibola apart from its antidiabetic effect.