Pharmacodynamic influence of vitamin C and Esomeprazole on gastro protection in pylorus ligation and aspirin induced ulcers in rats

Gastric ulcer is one of the most prevalent gastrointestinal disorders, which affects approximately 5–10% of people during their life. The present study was aimed to find out the pharmacodynamic influence of Vitamin C and Esomeprazole and their combination on Gastro intestinal parameters in pylorus ligation and aspirin induced ulcers in rats. In pylorus ligation induced ulcer model, various parameters were studied viz. gastric volume, pH, total acidity, free acidity, and ulcer index. Ulcer index and percentage inhibition of ulceration was determined for aspirin induced ulcer model. The antiulcer effect of the combination of vitamin C 4.5 mg/200 g and esomeprazole 0.54 mg/200 g b.w orally was compared with the reference standard esomeprazole 0.54 mg/200 g b.w orally. The ulcer index was calculated and other biochemical parameters of gastric juice were estimated. The ulcer index of combination showed significant (P < 0.05) reduction while other biochemical parameters like volume, pH, free acidity and total acidity of gastric juice showed highly significant (P < 0.001) reduction when compared to control and standard esomeprazole. The percentage protection of combination was 85% as compared to standard esomeprazole 80% in pylorus ligation model. In the aspirin induced model the percentage protection of combination was 90% as compared to standard esomeprazole 85%. Thus the combination group was found to be synergistic in nature when compared to esomeprazole alone in both the models.