Influence of Anastrozole on Glimepiride in Experimental Animals

The present study was aimed to find out the effect of multiple dose (7 days) treatment of anastrozole an anticancer drug on the hypoglycaemic activity of glimepiride in normal and diabetic rats. The study was intended to determine the pharmacodynamic parameters of drug interaction between glimepiride and anastrozole in normal and diabetic rats. The studies were conducted using a group of six normal and six diabetic rats of either sex. The experiment was conducted in four stages. Group of six animals were selected for each stage of experiment. These studies were conducted in the four group of the animals and dose of administered drug (glimepiride 0.1 mg/kg and anastrozole 0.004 mg/kg body weight). The drugs were administered orally. The blood samples were collected by tail vein at predetermined time intervals and glucose levels were estimated by GOD/POD method using semi autoanalyer. The results indicated that single and multiple dose treatment of anastrozole an anticancer drug altered the hypoglycaemic activity of glimepiride when administered alone and along with glimepiride in normal and diabetic rats. This may be due to the synergistic effect of anastrozole with glimepiride. The preliminary studies indicate the combination may be unsafe in diabetes associated with cancer.