Koringa College of Pharmacy, Korangi, Tallarevu (M), East Godavari Dist., Andhra Pradesh
*Corresponding Author: K. Satyavathi, Koringa College of Pharmacy, Korangi, Tallarevu (M), East Godavari Dist., Andhra Pradesh. Email – ksatyacharan@yahoo.com
Online published on 31 October, 2013.
The present study was undertaken to evaluate the cardiotonic activity of the aqueous, methanolic and chloroform extracts of the roots of Hemidesmus indicus and fruits of Terminalia bellirica, Terminalia chebula. The cardiotonic effect of aqueous, methanolic and chloroform extracts of the three plants was studied by using isolated frog heart perfusion technique (IFHP). Ringer solution without calcium was used as a vehicle for administration of aqueous, methanolic and chloroform extracts as test and digoxin as standard. A significant increase in the height of force of contraction (positive ionotropic effect) and decrease in heart rate (negative chronotropic effect) was observed and as compared to standard, test drug showed wide therapeutic index.
Cardiotinic activity, Frog heart perfusion technique, Digoxin, Therapeutic index, Hemidesmus indicus, Terminalia bellirica, Terminalia chebula
