1Department of Pharmacology, Hindu College of Pharmacy, Guntur, (A.P), India
2Department of Pharmacognosy, A. S. N College of Pharmacy, Guntur, (A.P), India
3Department of Pharmacology, Calcutta institute of pharmaceutical t A.H.S, Kolkata, India
*Corresponding Author: K. Sravanthi Department of Pharmacology, Hindu College of Pharmacy, Guntur, (A.P), India. Email- Kommuri.77@gmail.com
Online published on 31 October, 2013.
The anti-inflammatory effect of the alcoholic extract of Solanum surattense whole plant was assessed in the carrageenan-induced rat paw edema, the antinociceptive effect of the alcoholic extract of Solanum surattense, plant was studied using thermal and chemical-induced pain models using animals, at the doses of 100 and 200 mg/kg body weight. The acute toxicity and the phytochemical constituents of the extract were also determined. The estimated LD50 of the extract was 2gm/kg body weight. Extract significantly (P<0.05), dose-dependently demonstrated anti-inflammatory activity against acute inflammation induced by carrageenan and also the extract significantly (P<0.05) prolonged the pain reaction times in tail flick pain model, and reduced acetic acid –induced writhing. Phytochemical analysis revealed the presence of alkaloids, saponins, flavanoids and carbohydrates in the plant
Analgesic, anti-inflammatory, Carrageenan, acute toxicity, Solanum surattense
