1K.V.K College of Pharmacy, Affiliated to Jawaharlal Nehru Technological University, Hyderabad
2T.R.R College of Pharmacy, Affiliated to Jawaharlal Nehru Technological University, Hyderabad
3College of Pharmaceutical Sciences, Affiliated to Biju Patnaik University of Technology, Rourkela
*Corresponding Author: Praveen Kumar Uppala, Assistant Professor, K.V.K College of Pharmacy, Hayathnagar, Ranga Reddy District E-mail: praveen.chintu32@gmail.com, Telephone number: 09441479276
Online published on 21 November, 2013.
The main objective of the study to evaluate the Anti-depressant activity of seeds extract of Avena sativa in Forced swim test (FST), Tail Suspension test (TST) and antagonism of Apomorphine induced hypothermia in mice. Phytochemical screening showed presence of carbohydrates, alkaloids, flavanoids, steroids, glycosides, saponins, amino acids, gums and mucilage. MSEAS did not produce any lethal effect even upto 2000mg/kg, p.o during Acute Oral Toxicity study. In FST and TST, MSEAS showed diminution of duration of immobility time in 100mg/kg but not in 200mg/kg. In antagonism of Apomorphine induced hypothermia model, Desipramine but not both doses of MSEAS significantly antagonised the Apomorphine induced hypothermia. From the above finding concluding that, shortening of immobility time in the FST and TST indicating, MSEAS showed antidepressant activity acting either by the enhancement of central 5-HT or catecholamine neurotransmission and Antagonism of Apomorphine induced Hypothermia indicating, MSEAS was not acting through Adrenergic system.
Avena sativa, Antidepressant activity, Forced swim test, Tail suspension test, Antagonising apomorphine induced hypothermia
